Format

Send to

Choose Destination
FASEB J. 2019 Jul 31:fj201901004R. doi: 10.1096/fj.201901004R. [Epub ahead of print]

Hypothalamic leptin sensitivity and health benefits of time-restricted feeding are dependent on the time of day in male mice.

Boucsein A1,2, Rizwan MZ1,3,4, Tups A1,2,4.

Author information

1
Department of Physiology, Centre for Neuroendocrinology, Brain Health Research Centre, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.
2
Department of Animal Physiology, Faculty of Biology, Philipps University of Marburg, Marburg, Germany.
3
Department of Anatomy, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.
4
Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand.

Abstract

Synchronization between biologic clocks and metabolism is crucial for most species. Here, we examined the ability of leptin, important in the control of energy metabolism, to induce leptin signaling at the molecular as well as the behavioral level throughout the 24-h day in mice fed either a control or a high-fat diet (HFD). Furthermore, we investigated the effects of time-restricted feeding (TRF; a limitation of HFD access to 6 h each day) on energy metabolism during different periods throughout the 24-h day. In control mice, molecular leptin sensitivity was highest at zeitgeber time (ZT)0 (lights on), declining during the light phase, and increasing during the dark phase. Surprisingly, leptin resistance in HFD-fed mice was only present from the middle of the dark to the middle of the light period. Specifically, when TRF occurred from ZT21 to ZT3 (when leptin resistance in HFD-fed mice was most profound), it resulted in a disruption of the daily rhythms of locomotor activity and energy expenditure and in increased plasma insulin levels compared with other TRF periods. These data provide evidence that leptin sensitivity is controlled by the circadian rhythm and that TRF periods may be most efficient when aligned with the leptin-sensitive period.-Boucsein, A., Rizwan, M. Z., Tups, A. Hypothalamic leptin sensitivity and health benefits of time-restricted feeding are dependent on the time of day in male mice.

KEYWORDS:

biological clock; daily rhythm; diet; energy metabolism; periodic fasting

PMID:
31366239
DOI:
10.1096/fj.201901004R

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center