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Twin Res Hum Genet. 2019 Jul 31:1-9. doi: 10.1017/thg.2019.35. [Epub ahead of print]

The CODATwins Project: The Current Status and Recent Findings of COllaborative Project of Development of Anthropometrical Measures in Twins.

Silventoinen K1, Jelenkovic A2, Yokoyama Y3, Sund R1, Sugawara M4, Tanaka M5, Matsumoto S6, Bogl LH7, Freitas DL8, Maia JA9, Hjelmborg JVB10, Aaltonen S7, Piirtola M7, Latvala A11, Calais-Ferreira L12, Oliveira VC13, Ferreira PH14, Ji F15, Ning F15, Pang Z15, Ordoñana JR16, Sánchez-Romera JF16, Colodro-Conde L16, Burt SA17, Klump KL17, Martin NG18, Medland SE18, Montgomery GW19, Kandler C20, McAdams TA21, Eley TC21, Gregory AM22, Saudino KJ23, Dubois L24, Boivin M25, Brendgen M26, Dionne G25, Vitaro F27, Tarnoki AD28, Tarnoki DL28, Haworth CMA29, Plomin R21, Öncel SY30, Aliev F31, Medda E32, Nisticò L32, Toccaceli V32, Craig JM33, Saffery R34, Siribaddana SH35, Hotopf M36, Sumathipala A35, Rijsdijk F21, Jeong HU37, Spector T38, Mangino M38, Lachance G38, Gatz M39, Butler DA40, Gao W41, Yu C41, Li L41, Bayasgalan G42, Narandalai D43, Harden KP44, Tucker-Drob EM44, Christensen K10, Skytthe A10, Kyvik KO45, Derom CA46, Vlietinck RF46, Loos RJF47, Cozen W48, Hwang AE48, Mack TM48, He M49, Ding X49, Silberg JL50, Maes HH51, Cutler TL52, Hopper JL52, Magnusson PKE53, Pedersen NL53, Dahl Aslan AK53, Baker LA54, Tuvblad C54, Bjerregaard-Andersen M55, Beck-Nielsen H56, Sodemann M57, Ullemar V53, Almqvist C53, Tan Q58, Zhang D59, Swan GE60, Krasnow R61, Jang KL62, Knafo-Noam A63, Mankuta D64, Abramson L63, Lichtenstein P53, Krueger RF65, McGue M65, Pahlen S66, Tynelius P67, Rasmussen F67, Duncan GE68, Buchwald D68, Corley RP69, Huibregtse BM70, Nelson TL71, Whitfield KE72, Franz CE73, Kremen WS73, Lyons MJ23, Ooki S74, Brandt I75, Nilsen TS75, Harris JR75, Sung J76, Park HA77, Lee J76, Lee SJ76, Willemsen G78, Bartels M78, van Beijsterveldt CEM78, Llewellyn CH79, Fisher A79, Rebato E80, Busjahn A81, Tomizawa R82, Inui F83, Watanabe M82, Honda C82, Sakai N82, Hur YM37, Sørensen TIA84, Boomsma DI78, Kaprio J11.

Author information

1
Department of Social Research, Department University of Helsinki,Helsinki,Finland.
2
Department of Physiology, Faculty of Medicine and Nursing, University of the Basque Country,Leioa,Spain.
3
Department of Public Health Nursing, Osaka City University,Osaka,Japan.
4
Department of Psychology, Ochanomizu University,Tokyo,Japan.
5
Center for Forensic Mental Health, Chiba University,Chiba,Japan.
6
Institute for Education and Human Development, Ochanomizu University,Tokyo,Japan.
7
Institute for Molecular Medicine Finland FIMM,Helsinki,Finland.
8
Department of Physical Education and Sport, University of Madeira,Funchal,Portugal.
9
CIFI2D, Faculty of Sport, University of Porto,Porto,Portugal.
10
The Danish Twin Registry, Department of Public Health, Epidemiology, Biostatistics & Biodemography,University of Southern Denmark Odense,Denmark.
11
Department of Public Health, University of Helsinki,Helsinki,Finland.
12
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne,Melbourne,Australia.
13
Pós-Graduação em Reabilitação e Desempenho Funcional, Universidade Federal dos Vales do Jequitinhonha e Mucuri,Diamantina,Brazil.
14
Musculoskeletal Health Research Group, Faculty of Health Sciences, The University of Sydney,Sydney,Australia.
15
Department of Noncommunicable Diseases Prevention, Qingdao Centers for Disease Control and Prevention,Qingdao,China.
16
Department of Human Anatomy and Psychobiology, University of Murcia,Murcia,Spain.
17
Michigan State University,East Lansing, MI,USA.
18
QIMR Berghofer Medical Research Institute,Brisbane,Australia.
19
Institute for Molecular Bioscience, The University of Queensland,Brisbane,Australia.
20
Department of Psychology, University of Bremen,Bremen,Germany.
21
Social Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry,Psychology and Neuroscience, King's College London,UK.
22
Department of Psychology, Goldsmiths, University of London,London,UK.
23
Department of Psychological and Brain Sciences, Boston University,Boston, MA,USA.
24
School of Epidemiology and Public Health, University of Ottawa,Ottawa, Ontario,Canada.
25
École de psychologie, Université Laval,Québec,Canada.
26
Département de Psychologie, Université du Québec à Montréal,Montréal, Québec,Canada.
27
École de Psychoéducation, Université de Montréal,Montréal, Québec,Canada.
28
Department of Radiology, Semmelweis University,Budapest,Hungary.
29
MRC Integrative Epidemiology Unit, University of Bristol,Bristol,U.K.
30
Department of Statistics, Faculty of Arts and Sciences, Kırıkkale University,Kırıkkale,Turkey.
31
Psychology and African American Studies, Virginia Commonwealth University,Richmond, VA,USA.
32
Istituto Superiore di Sanità - Centre for Behavioural Sciences and Mental Health,Rome,Italy.
33
Centre for Molecular and Medical Research, Deakin University School of Medicine,Geelong,Australia.
34
Murdoch Children's Research Institute, Royal Children's Hospital,Parkville, Victoria,Australia.
35
Institute of Research & Development,Battaramulla,Sri Lanka.
36
Institute of Psychiatry Psychology and Neuroscience, King's College London,London,UK.
37
Department of Education, Mokpo National University,Jeonnam,South Korea.
38
Department of Twin Research and Genetic Epidemiology, King's College,London,UK.
39
Center for Economic and Social Research, University of Southern California,Los Angeles, CA,USA.
40
Health and Medicine Division, The National Academies of Sciences, Engineering, and Medicine,Washington, DC,USA.
41
Department of Epidemiology and Biostatistics, School of Public Health, Peking University,Beijing,China.
42
Healthy Twin Association of Mongolia,Ulaanbaatar,Mongolia.
43
Graduate School of Biomedical and Health Sciences, Hiroshima University,Hiroshima,Japan.
44
Department of Psychology, University of Texas at Austin,Austin, TX,USA.
45
Department of Clinical Research, University of Southern Denmark,Odense,Denmark.
46
Centre of Human Genetics, University Hospitals Leuven,Leuven,Belgium.
47
The Charles Bronfman Institute for Personalized Medicine, The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai,New York, NY,USA.
48
Department of Preventive Medicine, Keck School of Medicine of USC, University of Southern California,Los Angeles, CA,USA.
49
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University,Guangzhou,China.
50
Department of Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University,Richmond, VA,USA.
51
Department of Human and Molecular Genetics, Psychiatry & Massey Cancer Center, Virginia Commonwealth University,Richmond, VA,USA.
52
Twins Research Australia, Centre for Epidemiology and Biostatistics, The University of Melbourne,Melbourne,Australia.
53
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet,Stockholm,Sweden.
54
Department of Psychology, University of Southern California,Los Angeles, CA,USA.
55
Bandim Health Project, INDEPTH Network,Bissau,Guinea-Bissau.
56
Department of Endocrinology, Odense University Hospital,Odense,Denmark.
57
Department of Infectious Diseases, Odense University Hospital,Odense,Denmark.
58
Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark,Odense,Denmark.
59
Department of Public Health, Qingdao University Medical College,Qingdao,China.
60
Stanford Prevention Research Center, Department of Medicine, Stanford University School of Medicine,Stanford, CA,USA.
61
Center for Health Sciences, SRI International,Menlo Park, CA,USA.
62
Department of Psychiatry, University of British Columbia,Vancouver, BC,Canada.
63
The Hebrew University of Jerusalem,Jerusalem,Israel.
64
Hadassah Hospital Obstetrics and Gynecology Department, Hebrew University Medical School,Jerusalem,Israel.
65
Department of Psychology, University of Minnesota,Minneapolis, MN,USA.
66
Department of Psychology, University of California,Riverside, Riverside, CA,USA.
67
Department of Public Health Sciences, Karolinska Institutet,Stockholm,Sweden.
68
Washington State Twin Registry, Washington State University - Health Sciences Spokane,Spokane, WA,USA.
69
Institute for Behavioral Genetics, University of Colorado,Boulder, CO,USA.
70
Institute of Behavioral Science, University of Colorado,Boulder, CO,USA.
71
Department of Health and Exercise Sciences and Colorado School of Public Health, Colorado State University,Fort Collins, CO,USA.
72
Psychology and Neuroscience, Duke University,Durham, NC,USA.
73
Department of Psychiatry, University of California,San Diego, CA,USA.
74
Department of Health Science, Ishikawa Prefectural Nursing University,Kahoku, Ishikawa,Japan.
75
Division of Health Data and Digitalization, Norwegian Institute of Public Health,Oslo,Norway.
76
Department of Epidemiology, School of Public Health, Seoul National University,Seoul,Korea.
77
Department of Emergency Medicine, Hallym University Dongtan Sacred Heart Hospital,Hwaseong-si,South Korea.
78
Netherlands Twin Register, Department of Biological Psychology, Vrije Universiteit,Amsterdam, Amsterdam,Netherlands.
79
Health Behaviour Research Centre, Department of Epidemiology and Public Health, Institute of Epidemiology and Health Care, University College London,London,UK.
80
Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country UPV/EHU,Leioa,Spain.
81
HealthTwiSt GmbH,Berlin,Germany.
82
Center for Twin Research, Osaka University Graduate School of Medicine,Osaka,Japan.
83
Faculty of Health Science, Kio University,Nara,Japan.
84
Novo Nordisk Foundation Centre for Basic Metabolic Research (Section of Metabolic Genetics), Faculty of Health and Medical Sciences, University of Copenhagen,Copenhagen,Denmark.

Abstract

The COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) project is a large international collaborative effort to analyze individual-level phenotype data from twins in multiple cohorts from different environments. The main objective is to study factors that modify genetic and environmental variation of height, body mass index (BMI, kg/m2) and size at birth, and additionally to address other research questions such as long-term consequences of birth size. The project started in 2013 and is open to all twin projects in the world having height and weight measures on twins with information on zygosity. Thus far, 54 twin projects from 24 countries have provided individual-level data. The CODATwins database includes 489,981 twin individuals (228,635 complete twin pairs). Since many twin cohorts have collected longitudinal data, there is a total of 1,049,785 height and weight observations. For many cohorts, we also have information on birth weight and length, own smoking behavior and own or parental education. We found that the heritability estimates of height and BMI systematically changed from infancy to old age. Remarkably, only minor differences in the heritability estimates were found across cultural-geographic regions, measurement time and birth cohort for height and BMI. In addition to genetic epidemiological studies, we looked at associations of height and BMI with education, birth weight and smoking status. Within-family analyses examined differences within same-sex and opposite-sex dizygotic twins in birth size and later development. The CODATwins project demonstrates the feasibility and value of international collaboration to address gene-by-exposure interactions that require large sample sizes and address the effects of different exposures across time, geographical regions and socioeconomic status.

KEYWORDS:

BMI; Twins; birth size; education; height; heritability; international comparisons

PMID:
31364586
DOI:
10.1017/thg.2019.35

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