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Arch Environ Contam Toxicol. 2019 Jul 30. doi: 10.1007/s00244-019-00655-4. [Epub ahead of print]

Urinary Metal Concentrations and the Incidence of Hypertension Among Adult Residents Along the Yangtze River, China.

Author information

1
Department of Epidemiology and Biostatistics Statistics, School of Public Health, Anhui Medical University, No. 81 Meishan Road, Shushan Districts, Hefei, 230032, Anhui, People's Republic of China.
2
Ma'anshan Center for Disease Control and Provention, Ma'anshan, Anhui, People's Republic of China.
3
Yian Center for Disease Control and Provention, Tongling, Anhui, People's Republic of China.
4
Department of Epidemiology and Biostatistics Statistics, School of Public Health, Anhui Medical University, No. 81 Meishan Road, Shushan Districts, Hefei, 230032, Anhui, People's Republic of China. fenh@ahmu.edu.cn.
5
Central Laboratory of Preventive Medicine, School of Public Health, Anhui Medical University, Hefei, 230032, Anhui, People's Republic of China. fenh@ahmu.edu.cn.

Abstract

Metals from the natural environment have potential hypertension effects. However, relevant studies on this topic are few. A total of 1358 adults aged 18-74 years from Chizhou, Maanshan, and Tongling of Anhui Province participated in the baseline study from 2014 to 2015. The follow-up study was performed from 2016 to 2017. Inductively coupled plasma optical emission spectrometry (7000 DV) was used to measure urinary Cr, Mn, Fe, Cu, and Zn of residents. Urinary concentrations of Cd determined via TAS-900 atomic absorption spectrophotometry at 228.8 nm wavelength. A total of 275 hypertension cases were identified. After adjusting for sociodemographic factors and risk factors for hypertension, four metals (Cd, Cr, Cu, and Mn) were significantly associated with hypertension in the single-metal model. Upon including all metals in the same model, the hazard ratios of the highest quartiles Cd and Cu compared with the reference group were 1.42 (95% confidence interval [CI] 1.09-2.02) and 1.56 (95% CI 1.16-2.09) for cases of hypertension. Our findings suggested that high levels of Cd and Cu might increase the incidence of hypertension. Further studies involving larger population should be conducted to confirm these findings.

PMID:
31363802
DOI:
10.1007/s00244-019-00655-4

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