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Open Forum Infect Dis. 2019 Jul 1;6(7). pii: ofz288. doi: 10.1093/ofid/ofz288.

The Role of Fecal Microbiota Transplantation in Reducing Intestinal Colonization With Antibiotic-Resistant Organisms: The Current Landscape and Future Directions.

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Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.
Division of Infectious Diseases, Department of Internal Medicine, Rush Medical College, Chicago, Illinois.
Division of Infectious Diseases, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor.
Division of Infectious Diseases, John T. Milliken Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri.


The intestinal tract is a recognized reservoir of antibiotic-resistant organisms (ARO), and a potential target for strategies to reduce ARO colonization. Microbiome therapies such as fecal microbiota transplantation (FMT) have been established as an effective treatment for recurrent Clostridioides difficile infection and may be an effective approach for reducing intestinal ARO colonization. In this article, we review the current published literature on the role of FMT for eradication of intestinal ARO colonization, review the potential benefit and limitations of the use of FMT in this setting, and outline a research agenda for the future study of FMT for intestinal ARO colonization.


antibiotic resistance; antibiotic-resistant organism; fecal microbiota transplantation; hospital epidemiology; microbiome; multidrug-resistant organisms; resistome

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