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Cureus. 2019 May 24;11(5):e4743. doi: 10.7759/cureus.4743.

Growing Old Too Fast: A Rare Case of Werner Syndrome.

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Internal Medicine, University of Missouri-Kansas City School of Medicine, Kansas City, USA.
Hematology and Oncology, University of Cincinnati, Cincinnati, USA.
Endocrinology, University of Missouri-Kansas City School of Medicine, Kansas City, USA.


Werner syndrome (WS) is rare adult-onset progeria characterized by premature aging and early death. Patients develop normally until adolescence and usually present in early adulthood. Our case highlights a common presentation of this uncommon disease, wherein a 29-year-old non-obese male with no known risk factors developed uncontrolled diabetes, hypertriglyceridemia, and rapidly progressive atherosclerotic vascular disease. Careful observation with attention to the presence of characteristic physical features and subsequent genetic testing helped diagnose the patient with this uncommon progeroid syndrome. Our case adds to the literature about this rare disease especially in patients of middle-eastern descent and also highlights the importance of having a high index of suspicion for WS when the initial clinical presentation is atypical.


progeria; werner syndrome

Conflict of interest statement

The authors have declared that no competing interests exist.

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