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J Clin Invest. 1988 Aug;82(2):624-7.

Administration of an aldose reductase inhibitor induces a decrease of collagen fluorescence in diabetic rats.

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1
Department of Orthopaedics, Mount Sinai School of Medicine, New York 10029.

Abstract

As a consequence of an increased flux through the sorbitol pathway fructose levels rise in various tissues in diabetes. Also, in vitro nonenzymatic fructosylation of protein induces the generation of fluorescence at a rate 10 times greater than glucosylation. The administration of sorbinil, an aldose reductase inhibitor known to lower tissue fructose concentration, to experimental diabetic rats led to a decrease in the fluorescence related to advanced Maillard products in their skin collagen. This effect is consistent with the in vivo occurrence of nonenzymatic fructosylation of collagen. A potential pathogenetic role for this posttranslational modification in diabetic complications should be considered.

PMID:
3136193
PMCID:
PMC303557
DOI:
10.1172/JCI113641
[Indexed for MEDLINE]
Free PMC Article

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