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Indian J Pathol Microbiol. 2019 Jul-Sep;62(3):464-466. doi: 10.4103/IJPM.IJPM_305_18.

HPV related cloacogenic carcinoma of the anal canal with divergent histomorphology.

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Department of Histopathology, Bhagavan Pathology Laboratory, Mysore, Karnataka, India.


Cloacogenic carcinoma also known as basaloid squamous cell carcinoma is a rare anorectal tumor presenting with varied histomorphology. In this case report, we describe a case of 58-year-old man presenting with bleeding per rectum and pain. A polypoidal tumor was noted in anal canal which on microscopy was diagnosed to be cloacogenic carcinoma with transitional carcinoma-like, basaloid and mucinous patterns. An unusual finding in the present case was the presence of signet ring cells in the mucinous areas. A thorough knowledge of the wide histomorphological spectrum of the tumor and a limited IHC panel are crucial for the diagnosis. Here, we also present a review of literature and describe in detail the origin and histopathological features of the tumor.


Anal canal; basaloid carcinoma; basaloid squamous cell carcinoma; cloacogenic carcinoma; transitional cloacogenic carcinoma

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