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Indian J Pathol Microbiol. 2019 Jul-Sep;62(3):448-450. doi: 10.4103/IJPM.IJPM_319_18.

Xanthomatous hypophysitis: A rare case report with review of literature.

Author information

1
Department of Pathology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Karnataka, India.
2
Department of Neurosurgery, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Karnataka, India.

Abstract

Hypophysitis is classified into primary and secondary. Xanthomatous hypophysitis is one of the rare types of primary hypophysitis. A 55-year-old female presented with headache, vomiting, and blurring of vision. She also had endocrine dysfunction in the form of low serum T3, T4, and low cortisol levels. MRI scan showed a sellar expansile lesion suggestive of pituitary macroadenoma. Microscopy showed pituitary tissue replaced by inflammatory infiltrate made up of foamy histiocytes arranged in sheets along with lymphoplasmacytic infiltrate. Interspersed areas of fibrosis, hyalinization, few congested and sclerosed blood vessels were seen. Compressed residual pituitary tissue was identified at the periphery. Xanthomatous hypophysitis is a rare entity which can mimic as pituitary adenoma both clinically and radiologically. Accurate diagnosis at an early stage with postsurgical steroid therapy may help to prevent permanent pituitary damage.

KEYWORDS:

Hypophysitis; pituitary adenoma; xanthogranulomatous

PMID:
31361237
DOI:
10.4103/IJPM.IJPM_319_18
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