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Indian J Pathol Microbiol. 2019 Jul-Sep;62(3):445-447. doi: 10.4103/IJPM.IJPM_723_18.

Pigmented variant of pleomorphic xanthoastrocytoma - A rare long-term epilepsy associated neoplasm.

Author information

1
Department of Neuropathology, NIMHANS, Bengaluru, Karnataka, India.
2
Department of Neurosurgery, NIMHANS, Bengaluru, Karnataka, India.
3
Department of Neuroimaging and Interventional Radiology, NIMHANS, Bengaluru, Karnataka, India.

Abstract

Pleomorphic xanthoastrocytoma (PXA) is an uncommon, long-term epilepsy associated tumor of young adults. Its pigmented variant is exceedingly rare, with only five previously reported cases on record. We report the sixth case of pigmented PXA in a 24-year-old lady presenting with long-standing seizures. The MRI revealed a solid cystic lesion located in the right medial temporal lobe. Histopathologically, the superficially located tumor showed typical features of PXA with melanin-laden astrocytic component and was negative for V600E-mutant BRAF. The histogenesis is discussed.

KEYWORDS:

Epilepsy; V600E-mutant BRAF; histopathology; melanin; pleomorphic xanthoastrocytoma

PMID:
31361236
DOI:
10.4103/IJPM.IJPM_723_18
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