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Proceedings (IEEE Int Conf Bioinformatics Biomed). 2018 Dec;2018:1189-1194. doi: 10.1109/BIBM.2018.8621403. Epub 2019 Jan 24.

Supervised Nonnegative Matrix Factorization to Predict ICU Mortality Risk.

Author information

1
Feinberg School of Medicine, Northwestern University, Chicago, U.S.
2
Weill Cornell Medicine, Cornell University, New York, U.S.

Abstract

ICU mortality risk prediction is a tough yet important task. On one hand, due to the complex temporal data collected, it is difficult to identify the effective features and interpret them easily; on the other hand, good prediction can help clinicians take timely actions to prevent the mortality. These correspond to the interpretability and accuracy problems. Most existing methods lack of the interpretability, but recently Subgraph Augmented Nonnegative Matrix Factorization (SANMF) has been successfully applied to time series data to provide a path to interpret the features well. Therefore, we adopted this approach as the backbone to analyze the patient data. One limitation of the original SANMF method is its poor prediction ability due to its unsupervised nature. To deal with this problem, we proposed a supervised SANMF algorithm by integrating the logistic regression loss function into the NMF framework and solved it with an alternating optimization procedure. We used the simulation data to verify the effectiveness of this method, and then we applied it to ICU mortality risk prediction and demonstrated its superiority over other conventional supervised NMF methods.

KEYWORDS:

ICU mortality risk; Logistic regression; Nonnegative matrix factorization; Representation; Supervised learning

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