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Int J Prev Med. 2019 Jun 7;10:103. doi: 10.4103/ijpvm.IJPVM_367_18. eCollection 2019.

Effect of Training with or without Ziziphus Jujuba Extract on Cardiokines in Heart Tissue of Myocardial Infarcted Rats.

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Department of Exercise Physiology, Faculty of Sport Sciences, University of Isfahan, Isfahan, Iran.
Department of Animal Science, Faculty of Agriculture, University of Birjand, Birjand, Iran.



Today, the importance of physical activity as a preventative way for cardiovascular disease has attracted much attention.The aim of this study is to investigate the effect of 6 weeks of interval training with or without extract of Ziziphus jujuba on lipocalcin-2 (LCN2) and adiponectin levels in heart tissue in male Wistar rats with myocardial infarction.


Thirty male Wistar rats (mean weight, 180-220 g and age, 2-3 months) were divided into five groups, including (1) Healthy control; (2) Isoprenaline-treated group (ISO); (3) ISO + jujube extracts (JE); (4) Trained ISO rats; and (5) Trained ISO rats + JE. Exercise was performed (5 days/week, for 6 week including 54-min cycles with speed of 23 m/min and 54-min cycles with speed of 15 m/min). After 48 h of the last training session, the rats were sacrificed, and their heart tissue was excised. The significant level of statistical data was analyzed by one-way ANOVA test.


LCN2 levels significantly decreased in trained ISO rats + JE group after 6 weeks of interval training with JE consumption, compared to ISO group. However, the consumption of jujuba extracts with and without interval training did not show any significant changes in adiponectin levels of rat's heart tissue, compared to ISO (P < 0.05).


Because the LCN2 inflammatory factor decreased after 6 weeks of exercise and consumption of the extract, it seems that performing interval training with JE consumption can be an effective method in the cardiac rehabilitation phase after a heart attack.


Adiponectin; Ziziphus; exercise training; lipocalin-2; myocardial infarction

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