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Int J Prev Med. 2019 Jun 7;10:95. doi: 10.4103/ijpvm.IJPVM_116_18. eCollection 2019.

Leishmania Vaccines Entered in Clinical Trials: A Review of Literature.

Author information

1
Department of Pathobiology, Faculty of Veterinary Science, Bu-Ali Sina University, Hamedan, Iran.
2
Acquired Immunodeficiency Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
3
Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.

Abstract

Leishmaniasis is considered as a zoonotic infection and neglected tropical disease. Leishmania treatment is not totally successful and imposes high expenditures, especially in developing countries. Since the natural infection leads to the robust immunity in most of the human cases, many bodies of research have been focusing on Leishmania vaccines, being capable to control Leishmania infection. First generation vaccines (such as Leishmune® and CaniLeish®) have proved robust protective immunity in dogs. In human, recombinant vaccines, including Leish-F1 could confer some degrees of protective immunity against natural infection. Recently, ChAd63-KH DNA vaccine has been accomplished in providing prevention against Leishmania infection; however, this vaccine should be further evaluated in other clinical trials.

KEYWORDS:

Leishmania donovani; Leishmania major; Leishmania mexicana; Leishmania vaccines; Leishmnia amazonensis

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