Format

Send to

Choose Destination
Nat Cell Biol. 2019 Aug;21(8):952-965. doi: 10.1038/s41556-019-0364-8. Epub 2019 Jul 29.

Asymmetric inheritance of spindle microtubule-organizing centres preserves replicative lifespan.

Author information

1
Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Spanish National Research Council (CSIC), University of Seville, University Pablo de Olavide, Sevilla, Spain.
2
Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Spanish National Research Council (CSIC), University of Seville, University Pablo de Olavide, Sevilla, Spain. fernando.monje@cabimer.es.

Abstract

The differential distribution of the microtubule-organizing centres (MTOCs) that orchestrate spindle formation during cell division is a fascinating phenomenon originally described in Saccharomyces cerevisiae and later found to be conserved during stem cell divisions in organisms ranging from Drosophila to humans. Whether predetermined MTOC inheritance patterns fulfil any biological function is however unknown. Using a genetically designed S. cerevisiae strain that displays a constitutively inverted MTOC fate, we demonstrate that the asymmetric segregation of these structures is critical to ensure normal levels of the Sir2 sirtuin and correct localization of the mitochondrial inheritance regulator Mfb1, and therefore to properly distribute functional mitochondria and protein aggregates between the mother and daughter cells. Consequently, interfering with this process severely accelerates cellular ageing.

PMID:
31358968
DOI:
10.1038/s41556-019-0364-8

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center