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Lett Appl Microbiol. 2019 Jul 29. doi: 10.1111/lam.13201. [Epub ahead of print]

Nanoporous anodic alumina reduces Staphylococcus biofilm formation.

Author information

1
Department of Food Science, Cornell University, Ithaca, New York, USA.
2
Department of Mechanical, Aerospace and Nuclear Engineering, Rensselaer Polytechnic Institute, Troy, New York, USA.

Abstract

Staphylococcus epidermidis and Staphylococcus aureus, two bacterial strains commonly associated with biofilm-related medical infections and food poisoning, can rapidly colonize biotic and abiotic surfaces. The present study investigates the ability of anodic alumina surfaces with nanoporous surface topography to minimize the attachment and biofilm formation mediated by these pathogenic bacterial strains. Early attachment and subsequent biofilm development were retarded on surfaces with nanopores of 15-25 nm in diameter compared to surfaces with 50-100 nm pore diameter and nanosmooth surfaces. After 30 min of incubation in nutritive media, the biomass accumulation per unit surface area was 2·93 ± 1·72 μm3 μm-2 for the 15 nm, 3·49 ± 1·97 μm3 μm-2 for the 25 nm, as compared to 14·04 ± 6·39 μm3 μm-2 for the nanosmooth, 11·88 ± 9·72 μm3 μm-2 for the 50 nm, and 12·09 ± 11·84 μm3 μm-2 for the 100 nm surfaces, respectively. These findings suggest that anodic alumina with small size nanoscale pores could reduce the incidence of staphylococcal biofilms and infections, and shows promise as a material for a variety of medical applications and food contact surfaces. This article is protected by copyright. All rights reserved.

KEYWORDS:

Staphylococcus ; Anodized aluminum oxide; antifouling; biofilm; nanostructure

PMID:
31357240
DOI:
10.1111/lam.13201

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