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Int J Infect Dis. 2019 Oct;87:15-20. doi: 10.1016/j.ijid.2019.07.015. Epub 2019 Jul 26.

Ribavirin for the treatment of Lassa fever: A systematic review and meta-analysis.

Author information

1
Department of Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine and I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
2
Department of Virology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
3
Department of Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine and I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Electronic address: ramharter@bnitm.de.

Abstract

OBJECTIVES:

Lassa fever (LF) causes annual outbreaks in endemic regions with high mortality of symptomatic patients. Ribavirin is recommended as standard treatment for LF in national and international guidelines but the evidence base for this recommendation has been questioned recently.

METHODS:

We conducted a systematic review and included 6 studies providing efficacy data of ribavirin treatment for LF (PROSPERO protocol CRD42018103994).

RESULTS:

Besides retrospective case series, the evidence mostly relies on a single prospective clinical trial with critical risk of bias. In this trial, LF associated mortality is reduced for patients with elevated aspartate aminotransferase (AST) when treated with ribavirin (OR 0.41, 95% CI 0.23-0.73), while mortality is higher for patients without elevated AST (OR 2.37, 95% CI 1.07-5.25).

CONCLUSIONS:

Based on the available data, current treatment guidelines may therefore put patients with mild LF at increased risk of death. The role of ribavirin in the treatment of LF requires urgent reassessment.

KEYWORDS:

Haemorrhagic fever; LASV; Lassa fever; Ribavirin

PMID:
31357056
DOI:
10.1016/j.ijid.2019.07.015
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