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Pediatr Allergy Immunol. 2019 Jul 29. doi: 10.1111/pai.13112. [Epub ahead of print]

Children with wheat allergy usually tolerate oats.

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Skin and Allergy Hospital, Helsinki University Hospital and University of Helsinki, Finland.



Wheat is among the five most common foods causing allergy in young children. In about 70%, wheat allergy resolves by school age. Wheat-allergic children are frequently sensitized to oats, but they seem to tolerate ingested oats in their diet. Oats have been reported to cause non-IgE-mediated reactions and are a well-known elicitor of FPIES. On the contrary, IgE-mediated allergy to oats is rare, and only a few case reports on severe IgE-mediated reactions have been published.


The aim of this study was to evaluate whether oats-sensitized children with persistent wheat allergy tolerate ingested oats.


Fifteen children aged 9-16 years with a clinical history of severe wheat allergy were recruited. All children were sensitized to wheat, gliadin, and oats (specific IgE ≥0.35 kU/l and/or skin prick test ≥3 mm). Thirteen patients underwent an open oral wheat challenge; two patients were not challenged because of a severe reaction to wheat within the past 3 months. All 15 patients underwent an open oral oats challenge within 42 days.


All 13 wheat challenges were positive. Fourteen of the 15 oats challenges were negative with a cumulative dose of 1600mg protein. Only one patient had a positive oats challenge with a mild reaction at a cumulative dose of 600mg protein.


The majority of wheat-allergic, oats-sensitized children tolerate ingested oats. Oats can be safely tested at home if there is no clinical history of a reaction to oats. This article is protected by copyright. All rights reserved.


children; food allergy; food challenge; oats; specific IgE; wheat


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