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J Food Biochem. 2019 Jul;43(7):e12873. doi: 10.1111/jfbc.12873. Epub 2019 Apr 24.

Nephroprotective effects of red beetroot-based beverages against gentamicin-induced renal stress.

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National Institute of Food Science and Technology, Faculty of Food, Nutrition & Home Sciences, University of Agriculture, Faisalabad, Pakistan.
Medicinal Biochemistry Research Laboratory, Department of Biochemistry, University of Agriculture, Faisalabad, Pakistan.


The objective of this study was to assess the nephroprotective effects of red beetroot-based beverages to ameliorate gentamicin-induced renal stress. For the purpose, normal and nephrotoxicity-induced Sprague Dawley rats were pretreated with beetroot-based beverages (8 ml/kg per day) for 8 weeks. In nephrotoxicity-induced rats, renal stress was induced by administration of gentamicin at 85 mg/kg b.w. per day during the last week of the trial. Afterward, overnight-fasted rats were sacrificed, and their sera and kidneys were analyzed for renal health biomarkers which revealed ameliorative effect of red beet beverages. Particularly, the antioxidant enzymes in renal tissues and serum proteins were significantly improved, whereas lipid peroxidation, nitric oxide, urea and creatinine levels were momentously reduced in nephrotoxicity-induced rats. Furthermore, histological assessment indicated better renal portfolio in the rats treated with beet beverages. The findings suggested that red beetroot-based beverages promisingly ameliorate negative impacts of gentamicin-induced nephritic stress. PRACTICAL APPLICATIONS: High rates of morbidity arising from metabolic disorders have shifted the trends toward use of functional foods and nutraceuticals as a safer approach to avoid such ailments. This research checked the nephroprotective effect of beetroot-based beverages instead of extracts of red beetroot. The findings of this research support the use of red beetroot-based beverages as a promising approach to alleviate renal stress. Furthermore, dietary supplementation of functional products and nutraceutics derived from beetroot may be synchronized in clinical practices in future after sufficient research to avoid the onset of various degenerative disorders originating from oxidative/nitrosative stress. Before employing this dietary model to humans, further investigation is necessitated to observe safety in long-term administration of such products. Besides, therapeutic dietary modules can also be devised for already suffering individuals to manage the severity of the disease and help improving health.


antioxidants; beetroot-based beverages; gentamicin; nephroprotective; renal health markers


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