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J Math Neurosci. 2019 Jul 26;9(1):6. doi: 10.1186/s13408-019-0074-3.

Data-driven inference for stationary jump-diffusion processes with application to membrane voltage fluctuations in pyramidal neurons.

Author information

1
Department of Physics, University of Ottawa, Ottawa, Canada. melanson.alexandre@gmail.com.
2
Département de physique et d'astronomie, Université de Moncton, Moncton, Canada. melanson.alexandre@gmail.com.
3
Department of Physics, University of Ottawa, Ottawa, Canada.
4
Centre for Neural Dynamics, University of Ottawa, Ottawa, Canada.
5
Brain and Mind Research Institute, University of Ottawa, Ottawa, Canada.

Abstract

The emergent activity of biological systems can often be represented as low-dimensional, Langevin-type stochastic differential equations. In certain systems, however, large and abrupt events occur and violate the assumptions of this approach. We address this situation here by providing a novel method that reconstructs a jump-diffusion stochastic process based solely on the statistics of the original data. Our method assumes that these data are stationary, that diffusive noise is additive, and that jumps are Poisson. We use threshold-crossing of the increments to detect jumps in the time series. This is followed by an iterative scheme that compensates for the presence of diffusive fluctuations that are falsely detected as jumps. Our approach is based on probabilistic calculations associated with these fluctuations and on the use of the Fokker-Planck and the differential Chapman-Kolmogorov equations. After some validation cases, we apply this method to recordings of membrane noise in pyramidal neurons of the electrosensory lateral line lobe of weakly electric fish. These recordings display large, jump-like depolarization events that occur at random times, the biophysics of which is unknown. We find that some pyramidal cells increase their jump rate and noise intensity as the membrane potential approaches spike threshold, while their drift function and jump amplitude distribution remain unchanged. As our method is fully data-driven, it provides a valuable means to further investigate the functional role of these jump-like events without relying on unconstrained biophysical models.

KEYWORDS:

Channel noise; Chapman–Kolmogorov equation; Electric fish; Fokker–Planck equation; Jump-diffusion processes; Membrane noise; Pyramidal neurons; Stochastic differential equations

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