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Mol Cell. 2019 Jul 25;75(2):203-205. doi: 10.1016/j.molcel.2019.07.003.

Break Check: Transcription-Driven Topoisomerase II Collisions near Chromatin Loop Anchors Are Hotspots for DNA Damage and Translocations.

Author information

1
Genetics and Genome Biology Program, SickKids Research Institute, Toronto, ON, Canada.
2
Genetics and Genome Biology Program, SickKids Research Institute, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. Electronic address: michael.wilson@sickkids.ca.

Abstract

In this issue of Molecular Cell, Gothe, Maman et al. and Canela et al. demonstrate that type II topoisomerase (TOP2B/TOP2A)-mediated DNA breaks, and the oncogenic translocations they generate, are dependent on transcription and governed by chromatin architecture.

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