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Neurol India. 2019 May-Jun;67(3):724-727. doi: 10.4103/0028-3886.263191.

Guillain-Barre syndrome in North Indian children: Clinical and serial electrophysiological features.

Author information

1
Department of Pediatrics, Lady Hardinge Medical College and Associated Kalawati Saran Children's Hospital, New Delhi, India.
2
Division of Neurology, Department of Pediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada.

Abstract

Background:

Guillain-Barre syndrome (GBS) is a common acquired polyneuropathy in children.

Aim:

To describe the clinical and serial electrophysiological features along with short-term outcomes of children with GBS in north India.

Setting and Design:

This was a prospective study conducted at a tertiary care pediatric hospital in north India.

Materials and Methods:

Consecutive children, aged 2 to 18 years, with GBS, presenting within 4-weeks of onset of weakness, diagnosed on clinical and/or electrophysiological grounds, were enrolled. The enrolled children underwent a detailed clinical-assessment followed by nerve conduction studies. Repeat nerve conduction studies were performed after 2-weeks of the first study to determine changes in the electrophysiological subtype. The patients were followed up for 3 months.

Results:

Thirty-six children were studied. The mean age at presentation was 5.1 years [standard deviation (SD): 2.1]. The mean medical research council (MRC)-sum-score at admission was 24.1 (SD: 10.4). Thirty-three children (91%) had loss of ambulation, 24 (66%) had cranial nerve involvement, and 6 (16.6%) required ventilation. At presentation, 20 had acute motor axonal neuropathy (AMAN), 13 had acute inflammatory demyelinating polyneuropathy (AIDP), 2 had in-excitable nerves, and 1 had normal findings. Four children, initially diagnosed as AIDP, had AMAN with reversible conduction failure on the repeat study. The final classification was AMAN in 25 (69.4%; 95% confidence interval (CI), 51.9-83.7%) and AIDP in 9 children (25%; 95% CI, 12.1-42.2%). Only one patient was nonambulatory at a 3-month follow-up (n = 32). The Erasmus GBS outcome score was 2 in 2 (5.6%), 3 in 5 (13.9%), 4 in 26 (72.2%), and 5 in 3 (8.3%) patients.

Conclusions:

The serial electrophysiological studies were helpful in establishing the final correct diagnosis.

KEYWORDS:

Erasmus GBS outcome score; Guillain-Barre syndrome; reversible conduction failure; serial electrophysiological studies

PMID:
31347543
DOI:
10.4103/0028-3886.263191
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