Format

Send to

Choose Destination
Br J Pharmacol. 2019 Jul 26. doi: 10.1111/bph.14800. [Epub ahead of print]

Nitric oxide signalling in the brain and its control of bodily functions.

Chachlaki K1,2,3, Prevot V1,2,3.

Author information

1
Inserm, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Jean-Pierre Aubert Research Centre, UMR-S 1172, Lille, France.
2
School of Medicine, University of Lille, Lille, France.
3
CHU Lille, FHU 1,000 days for Health, Lille, France.

Abstract

Nitric oxide (NO) is a versatile molecule that plays key roles in the development and survival of mammalian species by endowing brain neuronal networks with the ability to make continual adjustments to function in response to moment-to-moment changes in physiological input. Here, we summarize the progress in the field and argue that NO-synthetizing neurons and NO signalling in the brain provide a core hub for integrating sensory- and homeostatic-related cues, control key bodily functions, and provide a potential target for new therapeutic opportunities against several neuroendocrine and behavioural abnormalities.

PMID:
31347144
DOI:
10.1111/bph.14800

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center