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Vaccine. 2019 Jul 22. pii: S0264-410X(19)30929-6. doi: 10.1016/j.vaccine.2019.07.038. [Epub ahead of print]

Molecular epidemiology and intercontinental spread of cholera.

Author information

1
Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, United Kingdom; Translational Health Science and Technology Institute, Faridabad, Haryana 121001, India; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1S, United Kingdom. Electronic address: am872@medschl.cam.ac.uk.
2
Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, United Kingdom; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1S, United Kingdom.

Abstract

Whole genome sequence analysis has revealed the phylogenetic structure of Vibrio cholerae and has shown that the current seventh pandemic is highly clonal, emerging from a single source. Such analysis has the potential to become a powerful public health tool as we build public sequence databases, and as the speed of sequencing and analysis increases. Examples of such studies, as applied to different settings of the disease cholera, are described and discussed.

KEYWORDS:

Cholera; Epidemic; Epidemiology; Genomics; Outbreak; Pandemic; Spread; Transmission; Vaccine; Vibrio

PMID:
31345641
DOI:
10.1016/j.vaccine.2019.07.038
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