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Zhongguo Zhong Yao Za Zhi. 2019 May;44(9):1921-1926. doi: 10.19540/j.cnki.cjcmm.20190128.001.

[Screening of serum susceptibility biomarkers in patients with mild liver function abnormalities based on non-targeted metabolomics].

[Article in Chinese]

Author information

1
Henan Province Engineering Laboratory for Clinical Evaluation Technology of Chinese Medicine,the First Affiliated Hospital of Henan University of Chinese Medicine Zhengzhou 450000,China.
2
Henan University of Chinese Medicine Zhengzhou 450046,China.
3
China Military Institute of Chinese Medicines,302 Military Hospital of China Beijing 100039,China.

Abstract

In the present study,non-targeted metabolomics technique was used to screen potentially susceptibility biomarkers in patients with mild liver function abnormalities during long-term use of Chinese herbal compound. According to the inclusion and exclusion criteria,we collected 7 cases of patients with abnormal liver function during the period of complete taking Chinese herbal medicine( 60 days),and 18 cases of patients with normal liver function in re-examination from the reproductive medicine center in our hospital. Ultra performance liquid chromatography coupled with time-of-flight mass spectrometry( UPLC-Q-TOF/MS~E) technique combined with Progenesis QI software was used to analyze the differential biomarkers in serum of patients with wild liver function abnormalities and normal liver function. 11 potential biomarkers such as bilirubin,pantothenic acid,hippuric acid,sphingomyelin,palmitic acid,and oleic acid were tentatively identified. Metabolic disorders in patients with herbal-induced mild liver abnormality were mainly related to two pathways: pantothenic acid and coenzyme A biosynthesis and linoleic acid metabolism. It could provide a reference for the early warning of mild liver function abnormalities of patients that may be caused by long-term use of Chinese medicine compound in clinical application,and will lay a foundation for further understanding the endogenous substance changes in different levels of liver injury.

KEYWORDS:

Chinese herbal medicine; biomarkers; endogenous small molecules; mild liver function abnormalities; non-targeted metabolomics

[Indexed for MEDLINE]

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