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Nutrients. 2019 Jul 12;11(7). pii: E1578. doi: 10.3390/nu11071578.

The Potential Use of Metabolic Cofactors in Treatment of NAFLD.

Author information

1
Science for Life Laboratory, KTH-Royal Institute of Technology, SE-17121 Stockholm, Sweden. adilm@scilifelab.se.
2
Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London SE1 9RT, UK. adilm@scilifelab.se.
3
School of Medicine, Koç University, Istanbul 34450, Turkey.
4
Department of Gastroenterology and Hepatology, School of Medicine, Koç University, Istanbul 34450, Turkey.
5
Science for Life Laboratory, KTH-Royal Institute of Technology, SE-17121 Stockholm, Sweden.
6
Department of Molecular and Clinical Medicine, University of Gothenburg and Sahlgrenska University Hospital Gothenburg, 41345 Gothenburg, Sweden.

Abstract

Non-alcoholic fatty liver disease (NAFLD) is caused by the imbalance between lipid deposition and lipid removal from the liver, and its global prevalence continues to increase dramatically. NAFLD encompasses a spectrum of pathological conditions including simple steatosis and non-alcoholic steatohepatitis (NASH), which can progress to cirrhosis and liver cancer. Even though there is a multi-disciplinary effort for development of a treatment strategy for NAFLD, there is not an approved effective medication available. Single or combined metabolic cofactors can be supplemented to boost the metabolic processes altered in NAFLD. Here, we review the dosage and usage of metabolic cofactors including l-carnitine, Nicotinamide riboside (NR), l-serine, and N-acetyl-l-cysteine (NAC) in human clinical studies to improve the altered biological functions associated with different human diseases. We also discuss the potential use of these substances in treatment of NAFLD and other metabolic diseases including neurodegenerative and cardiovascular diseases of which pathogenesis is linked to mitochondrial dysfunction.

KEYWORDS:

N-acetyl-l-cysteine; NAFLD; l-carnitine; l-serine; metabolic cofactors; nicotinamide riboside

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