Format

Send to

Choose Destination
Int J Mol Sci. 2019 Jul 12;20(14). pii: E3427. doi: 10.3390/ijms20143427.

Human DNA Virus Exploitation of the MAPK-ERK Cascade.

Author information

1
Department of Molecular and Biomedical Sciences, The University of Maine, Orono, ME 04401, USA.
2
Department of Molecular and Biomedical Sciences, The University of Maine, Orono, ME 04401, USA. melissa.maginnis@maine.edu.
3
Graduate School in Biomedical Sciences and Engineering, The University of Maine, Orono, ME 04401, USA. melissa.maginnis@maine.edu.

Abstract

The extracellular signal-regulated kinases (ERKs) comprise a particular branch of the mitogen-activated protein kinase cascades (MAPK) that transmits extracellular signals into the intracellular environment to trigger cellular growth responses. Similar to other MAPK cascades, the MAPK-ERK pathway signals through three core kinases-Raf, MAPK/ERK kinase (MEK), and ERK-which drive the signaling mechanisms responsible for the induction of cellular responses from extracellular stimuli including differentiation, proliferation, and cellular survival. However, pathogens like DNA viruses alter MAPK-ERK signaling in order to access DNA replication machineries, induce a proliferative state in the cell, or even prevent cell death mechanisms in response to pathogen recognition. Differential utilization of this pathway by multiple DNA viruses highlights the dynamic nature of the MAPK-ERK pathway within the cell and the importance of its function in regulating a wide variety of cellular fates that ultimately influence viral infection and, in some cases, result in tumorigenesis.

KEYWORDS:

cellular signaling; infection; mitogen-activated protein kinase; viruses

Supplemental Content

Full text links

Icon for Multidisciplinary Digital Publishing Institute (MDPI) Icon for PubMed Central
Loading ...
Support Center