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Nutrients. 2019 Jul 22;11(7). pii: E1678. doi: 10.3390/nu11071678.

Daily Intake of Fermented Milk Containing Lactobacillus casei Shirota (Lcs) Modulates Systemic and Upper Airways Immune/Inflammatory Responses in Marathon Runners.

Author information

1
Department of Otorhinolaryngology, Federal University of São Paulo (UNIFESP), São Paulo-SP 04039-032, Brazil.
2
Institute of Physical Activity Science and Sport, Cruzeiro of Sul University, São Paulo-SP 01506-000, Brazil.
3
Department of Physiology, Federal University of São Paulo (UNIFESP), São Paulo-SP 04023-062, Brazil.
4
Department of Morphology, Federal University of São Paulo (UNIFESP), São Paulo-SP 04023-900, Brazil.
5
Department of Orthopaedics and Traumatology, Federal University of São Paulo (UNIFESP), São Paulo-SP 04024-002, Brazil.
6
Environmental and Experimental Pathology, Paulista University (UNIP), São Paulo-SP 04043-200, Brazil.
7
Children´s Institute, Faculty of Medicine, University of São Paulo, São Paulo-SP 05403-000, Brazil.
8
Post-graduation Program in Bioengineering and in Biomedical Engineering, Universidade Brasil, São Paulo-SP 08230-030, Brazil.
9
Post-graduation Program in Sciences of Human Movement and Rehabilitation, Federal University of São Paulo (UNIFESP), Santos-SP 11060-001, Brazil.
10
Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE), São José Dos Campos-SP 12245-520, Brazil.
11
School of Medicine, Anhembi Morumbi University, São José dos Campos-SP 12230-002, Brazil.
12
Department of Otorhinolaryngology, Federal University of São Paulo (UNIFESP), São Paulo-SP 04039-032, Brazil. allbachi77@gmail.com.
13
Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE), São José Dos Campos-SP 12245-520, Brazil. allbachi77@gmail.com.

Abstract

BACKGROUND:

Although Lactobacillus casei Shirota (LcS) can benefit the immune status, the effects of LcS in the immune/inflammatory responses of marathon runners has never been evaluated. Therefore, here we evaluated the effect of daily ingestion of fermented milk containing or not LcS in the systemic and upper airway immune/inflammatory responses before and after a marathon.

METHODS:

Forty-two male marathon runners ingested a fermented milk containing 40 billion of LcS/day (LcS group, n = 20) or placebo (unfermented milk, n = 22) during 30 days pre-marathon. Immune/inflammatory parameters in nasal mucosa and serum, as well as concentrations of secretory IgA (SIgA) and antimicrobial peptides in saliva, were evaluated before and after fermented milk ingestion, immediately, 72 h, and 14 d post-marathon.

RESULTS:

Higher proinflammatory cytokine levels in serum and nasal mucosa, and also lower salivary levels of SIgA and antimicrobial peptides, were found immediately post-marathon in the placebo group compared to other time points and to LcS group. In opposite, higher anti-inflammatory levels and reduced neutrophil infiltration on nasal mucosa were found in the LcS group compared to other time points and to the placebo group.

CONCLUSION:

For the first time, it is shown that LcS is able to modulate the systemic and airways immune responses post-marathon.

KEYWORDS:

antimicrobial peptides; cytokines; neutrophil infiltration; probiotics; secretory immunoglobulin A

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