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Diabetes Metab Syndr. 2019 Mar - Apr;13(2):1187-1191. doi: 10.1016/j.dsx.2019.01.035. Epub 2019 Jan 24.

Ketogenic diet rescues cognition in ApoE4+ patient with mild Alzheimer's disease: A case study.

Author information

1
Human Bioenergetics & Applied Health Science, Bethel University, MN, USA.
2
Behavioral Health Sciences, Human Bioenergetics & Applied Health Science, Bethel University, MN, USA. Electronic address: kelly-gibas@bethel.edu.

Abstract

It has been established that there is a correlation between Alzheimer's disease and apolipoprotein E, specifically the ApoE4 genetic variant. However, the correlation between Apoe4, insulin resistance and metabolic syndrome (MetS) pathologies still remains elusive. As apolipoprotein E has many important physiological functions, individuals with the ApoE4 allele variant, also known as the Alzheimer's disease gene, are primarily at a greater risk for physiological consequences, specifically cognitive impairment (Chan et al., 2016). In this case study, a 71-year old female, heterozygous for ApoE4 with a family history of Alzheimer's Disease (AD) and the dual diagnosis of mild AD/metabolic syndrome (MetS) was placed on a 10-week nutrition protocol purposed at raising plasma ketones through carbohyrdrate restricted, high fat ketogenic diet (KD), time- restricted eating and physical/cognitive exercise. Primary biomarkers for MetS were measured pre/mid-/post intervention. The MoCA (Montreal Cognitive Assessment) was administered pre/post intervention by a licensed clinical therapist. The results were statistically significant. The HOMA-IR decreased by 75% from 13.9 to 3.48. Triglycerides decreased by 50% from 170mg/dL to 85mg/dL. VLDL dropped by 50% from 34mg/dL to 17mg/dL, and HgA1c decreased from 5.7% to 4.9%. The baseline MoCA score was 21/30; post treatment score was 28/30. The significant results in both MetS biomarkers and the MoCA score suggest that a ketogenic diet may serve to rescue cognition in patients with mild AD. The results of this case study are particularly compelling for ApoE4 positive (ApoE4+) subjects as ketogenic protocols extend hope and promise for AD prevention.

KEYWORDS:

Alzheimer's disease (AD); ApoE4; Ketogenic diet; Mild cognitive impairment (MCI)

PMID:
31336463
DOI:
10.1016/j.dsx.2019.01.035

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