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Diabetes Metab Syndr. 2019 Mar - Apr;13(2):1087-1091. doi: 10.1016/j.dsx.2019.01.022. Epub 2019 Jan 18.

Effect of Low Level Laser Therapy on serum vitamin D and magnesium levels in patients with diabetic peripheral neuropathy - A pilot study.

Author information

1
Department of Medical Laboratory Technology, School of Allied Health Sciences, Manipal Academy of Higher Education, Manipal, India.
2
Department of Physiotherapy, School of Allied Health Science, Manipal Academy of Higher Education, Manipal, India.
3
Department of Medical Laboratory Technology, School of Allied Health Sciences, Manipal Academy of Higher Education, Manipal, India. Electronic address: Saleena.ummer@manipal.edu.

Abstract

BACKGROUND:

Diabetic Peripheral neuropathy (DPN) is the most distressing complication of diabetic population leading to loss of sensation, pain, and amputation. Low-level laser therapy (LLLT) has been used to manage nerve injuries as it holds the potential to induce a biostimulatory effect with no side effects. Hence we planned to study the biochemical effect and therapeutic outcomes of LLLT on patients with painful diabetic peripheral neuropathy as a preliminary work.

MATERIALS AND METHODS:

Pre-posttest analysis was done on 40 patients diagnosed with DPN confirmed using 10 g Monofilament test and Michigan Neuropathy Screening Instrument (MNSI). Vibration sensation and pain measured by Vibration perception threshold (VPT) and Numeric pain rating scale (NPRS). All patients were given LLLT (3.1 J/cm2) on plantar and dorsal of the foot for 10 days. Serum samples were collected at baseline and 4 weeks after LLLT to estimate Vitamin D and Magnesium and compared the results.

RESULTS:

There was a significant increase in Vitamin D and Magnesium levels after LLLT. We observed a considerable improvement in the quality of life after LLLT demonstrated by a decrease in VPT and MNSI and a reduction in NPRS in DPN patients.

CONCLUSION:

In this study, we found that LLLT improved the QL and hence may be a useful therapeutic option in treating peripheral neuropathic pain in type 2 diabetic patients. The progress in the serum Magnesium and Vit. D levels were proportional to the QL and may be a good indicator of the prognosis of DPN after LLLT.

KEYWORDS:

Diabetic peripheral neuropathy; Low-level laser therapy; Neuropathic pain; Serum magnesium; Vitamin D

PMID:
31336449
DOI:
10.1016/j.dsx.2019.01.022

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