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Neuropeptides. 1988 Apr;11(3):95-100.

Extensive co-localization of neurotensin with dopamine in rat meso-cortico-frontal dopaminergic neurons.

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Chaire de Neuropharmacologie, INSERM U.114, Coll├Ęge de France, Paris.


In mammalian brain, dopaminergic (DA) cell bodies located in the ventral mesencephalon give rise to meso-cortical, meso-limbic and meso-striatal systems. Among these, the meso-cortical DA pathway is particularly involved in the processing of emotional and cognitive responses. We demonstrate that the rat meso-cortical neurons specifically contain, in addition to DA, another transmitter, Neurotensin. If this co-localization exists in man, it may provide an anatomical substratum for the biological theory of schizophrenia as well as an indication that potential anti-psychotic drugs which act differentially on the DA ascending transmissions can be developed.

[Indexed for MEDLINE]

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