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Int J Crit Illn Inj Sci. 2019 Apr-Jun;9(2):101-104. doi: 10.4103/IJCIIS.IJCIIS_72_18.

Bladder necrosis and perforation in end-stage renal disease and recurrent urinary tract infection: A rare medical emergency.

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Department of Internal Medicine, Grady Memorial Hospital, Atlanta, Georgia, USA.
Department of Gastroenterology, Morehouse School of Medicine, Grady Memorial Hospital, Atlanta, Georgia, USA.
Department of Colorectal Surgery, Morehouse School of Medicine, Grady Memorial Hospital, Atlanta, Georgia, USA.


Bladder necrosis and perforation is a rare and life-threatening medical emergency. Risk factors include trauma, malignancy, previous surgery and/or radiation therapy and diabetes mellitus. Signs, symptoms, and imaging findings are often obscure making the diagnosis difficult. Urinary tract infection is common in end-stage renal disease (ESRD) patients who have residual urine production and associated with increased complication and mortality rates. We describe the case of a 57-year-old female with a medical history of recurrent cystitis, type 2 diabetes mellitus and ESRD on hemodialysis that was admitted for septic shock and presumed ischemic colitis. Urine and blood microbiology studies were notable for Escherichia coli. By the second day of hospital admission, her clinical condition significantly deteriorated and was later found to have bladder necrosis and rupture during laparotomy for suspected peritonitis. It is important that clinicians recognize bladder rupture as a potential complication of recurrent bacterial cystitis in ESRD patients on dialysis.


Bladder rupture; end-stage renal disease; infection; peritonitis; sepsis

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