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Indian J Ophthalmol. 2019 Aug;67(8):1371-1373. doi: 10.4103/ijo.IJO_2009_18.

A rare masquerade of chalazion: Adenoid cystic carcinoma.

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Oculoplasty and Ocular Oncology Services, Centre for Sight Hospital, New Delhi, India.
Ocular Pathology Services, Centre for Sight Hospital, Hyderabad, Telangana, India.


Adenoid cystic carcinoma (ACC) is a rarely seen malignant epithelial tumor of the eyelids. We present a rare case of primary ACC arising from the tarsal plate of the lower lid that clinically resembled a chalazion. A 66-year-old female presented with a recurring nodule in her left lower lid. She gave history of surgery for chalazion removal from the same site twice earlier. An initial diagnosis of a recurrent chalazion was made, and incision and curettage was done. Light microscopy showed a solid tumor composed predominantly of sheet-like and nested pattern of basaloid to low-columnar cells with intervening fibrovascular septa and lacking an obvious cribriform or tubular architecture. The tumor cells were positive for pan-cytokeratin and CD117 and negative for adipophilin, HMB45, and BerEP4. A diagnosis of solid variant of ACC of the eyelid was made. Wide excision was performed and eyelid defect was reconstructed.


Adenoid cystic carcinoma; chalazion; eyelid malignancy

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