Send to

Choose Destination
Complement Ther Med. 2019 Aug;45:149-155. doi: 10.1016/j.ctim.2019.06.008. Epub 2019 Jun 14.

The effect of Nigella sativa L. supplementation on serum C-reactive protein: A systematic review and meta-analysis of randomized controlled trials.

Author information

Student Research Committee, School of Health, Kerman University of Medical Sciences, Kerman, Iran; Department of Nutrition, School of Health, Kerman University of Medical Sciences, Kerman, Iran.
Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research center, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Internal Medicine, Evangelismos General Hospital, Athens, Greece.
Faculty Research Centre for Sport, Exercise and Life Sciences, Coventry University, Coventry, UK.
Halal Research Center of IRI, FDA, Tehran, Iran. Electronic address:
Department of Cellular and molecular Nutrition, School of Nutritional sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran; Students' Scientific Research Center (SSRC), Tehran University of Medical Sciences (TUMS), Tehran, Iran. Electronic address:
Department of Nutrition, School of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.



Evidence on the efficacy ofNigella sativa supplementation is equivocal, thus the aim of this systematic review and meta-analysis of randomized clinical trials (RCTs) was to examine the effect of Nigella sativa (N. sativa) supplementation on plasma C-reactive protein (CRP) concentrations.


PubMed, Scopus, ISI Web of Science, Cochrane library, and Google Scholar databases were searched (up to April 2019) to identify RCTs investigating the effects of N. sativa seed and seed oil supplementation on CRP. Weighted mean differences (WMD) was pooled using a random-effects model. Standard methods were also used for assessment of heterogeneity, sensitivity analysis, and publication bias.


Eventually only five articles which reported data of interest entered for data analysis. The meta-analysis showed a significant reduction in serum CRP (WMD: -0.55 mg/L, 95% CI: -1.02, -0.08, P = 0.02), with significant heterogeneity between selected studies (I2 = 77.3%). Between-study heterogeneity disappeared following subgroup analysis, stratified by baseline BMI (≥30 kg/m2: I2 = 2.8%). However, the effect of N. sativa seed and seed oil supplementation on CRP was only significant in studies that were conducted on participants with BMI ≥ 30 kg/m2 (WMD: -0.50 mg/L, 95% CI: -0.85, -0.15).


This meta-analysis suggests thatN. sativa seed and seed oil supplementation can significantly reduce serum CRP level. However, RCTs with a larger sample size and longer follow-up periods should be conducted for future investigations to confirm the veracity of these results.


C-reactive protein; Meta-analysis; N. sativa; Randomized controlled trial


Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center