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Nutrients. 2019 Jul 19;11(7). pii: E1653. doi: 10.3390/nu11071653.

Assessing the Lifetime Cost-Effectiveness of Low-Protein Infant Formula as Early Obesity Prevention Strategy: The CHOP Randomized Trial.

Author information

1
Mannheim Institute of Public Health, Social and Preventive Medicine, Mannheim Medical Faculty of the Heidelberg University, 68167 Mannheim, Germany. mail@diana-sonntag.eu.de.
2
Department of Health Sciences, University of York, Heslington, York YO10 5DDY, UK. mail@diana-sonntag.eu.de.
3
Mannheim Institute of Public Health, Social and Preventive Medicine, Mannheim Medical Faculty of the Heidelberg University, 68167 Mannheim, Germany.
4
Federal Centre for Health Education, D-50825 Cologne, Germany.
5
Department of Pediatrics, Dr. von Hauner Children's Hospital, University of Munich Medical Centre, 80337 Munich, Germany.

Abstract

BACKGROUND:

Although there is a growing number of early childhood obesity prevention programs, only a few of them are effective in the long run. Even fewer reports exist on lifetime cost-effectiveness of early prevention strategies. This paper aimed to assess the lifetime cost-effectiveness of infant feeding modification aiming at reducing risk of later obesity.

METHODS:

The simulation model consists of two parts: (a) Model I used data from the European Childhood Obesity Project (CHOP) trial (up to 6 years) and the German Interview and Examination Survey for Children (KiGGS) (6-17 years) to evaluate BMI trajectories of infants receiving either lower protein (LP) or higher protein (HP) content formula; and (b) Model II estimated lifetime cost-effectiveness based on Model I BMI trajectories. Compared to HP formula, LP formula feeding would incur lower costs that are attributable to childhood obesity across all decades of life.

RESULTS:

Our analysis showed that LP formula would be cost-effective in terms of a positive net monetary benefit (discounted 3%) as an obesity prevention strategy. For the 19% of infants fed with formula in Germany, the LP strategy would result in cost savings of € 2.5 billion.

CONCLUSIONS:

Our study is one of the first efforts to provide much-needed cost-effectiveness evidence of infant feeding modification, thereby potentially motivating interventionists to reassess their resource allocation.

KEYWORDS:

childhood; cost-effectiveness; early nutrition; formula; markov model; obesity prevention

PMID:
31331027
PMCID:
PMC6682975
DOI:
10.3390/nu11071653
[Indexed for MEDLINE]
Free PMC Article

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