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Biomed Pharmacother. 2019 Oct;118:109210. doi: 10.1016/j.biopha.2019.109210. Epub 2019 Jul 19.

Arginine metabolism and deprivation in cancer therapy.

Author information

1
Department of Burn and Plastic Surgery, Shenzhen Longhua District Central Hospital, Shenzhen, China.
2
Department of Burn and Plastic Surgery, Shenzhen Longhua District Central Hospital, Shenzhen, China. Electronic address: kekey88@163.com.
3
Department of Burn and Plastic Surgery, Shenzhen Longhua District Central Hospital, Shenzhen, China; Division of Respiratory Medicine, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong Special Administrative Region. Electronic address: xushi_cn@163.com.

Abstract

Certain cancer cells with nutrient auxotrophy and have a much higher nutrient demand compared with normal human cells. Arginine as a versatile amino acid, has multiple biological functions in metabolic and signaling pathways. Depletion of this amino acid by arginine depletor is generally well tolerated and has become a targeted therapy for arginine auxotrophic cancers. However, the modulatory eff ;ect of arginine on cancer cells is very complicated and still controversial. Therefore, this article focuses on arginine metabolism and depletion therapy in cancer treatment to provide systemical review on this issue.

KEYWORDS:

Arginine; Cancer; Deprivation; Metabolism

PMID:
31330440
DOI:
10.1016/j.biopha.2019.109210
[Indexed for MEDLINE]
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