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Curr Opin Cell Biol. 2019 Jul 19;60:131-138. doi: 10.1016/j.ceb.2019.06.001. [Epub ahead of print]

Neural stem cell dynamics: the development of brain tumours.

Author information

1
The Gurdon Institute and Department of Physiology, Development and Neuroscience, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK.
2
The Gurdon Institute and Department of Physiology, Development and Neuroscience, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK. Electronic address: a.brand@gurdon.cam.ac.uk.

Abstract

Determining the premalignant lesions that develop into malignant tumours remains a daunting task. Brain tumours are frequently characterised by a block in differentiation, implying that normal developmental pathways become hijacked during tumourigenesis. However, the heterogeneity of stem cells and their progenitors in the brain suggests there are many potential routes to tumour initiation. Studies in Drosophila melanogaster have enhanced our understanding of the tumourigenic potential of distinct cell types in the brain. Here we review recent studies that have improved our knowledge of neural stem cell behaviour during development and in brain tumour models.

PMID:
31330360
DOI:
10.1016/j.ceb.2019.06.001

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