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AIDS. 1988 Apr;2(2):95-100.

HIV-2 antisera cross-neutralize HIV-1.

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Chester Beatty Laboratories, Institute of Cancer Research, London, UK.


The neutralization properties of three independent HIV-2 isolates were examined in comparison with four diverse HIV-1 strains. Human sera containing antibodies specific to HIV-2 can cross-neutralize HIV-1. By contrast, HIV-1 sera are group-specific and have no neutralizing effect on HIV-2. Therefore, HIV-2 antigens may be important components for the development of broadly cross-protective AIDS vaccines.

[Indexed for MEDLINE]

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