Send to

Choose Destination
J Gynecol Oncol. 2019 Sep;30(5):e72. doi: 10.3802/jgo.2019.30.e72.

Prior uterine myoma and risk of ovarian cancer: a population-based case-control study.

Author information

Department of Obstetrics and Gynecology, Taichung Veterans General Hospital, Taichung, Taiwan.
Department of Nursing, Hungkuang University, Taichung, Taiwan.
Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.
Big Data Center, China Medical University Hospital, Taichung, Taiwan.
Department of Public Health, Fu-Jen Catholic University, New Taipei, Taiwan.
Department of Health Care Management, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan.
Contributed equally



Uterine myoma which results in the magnitude of ovarian cancer remains uncertain. This study aimed to assess the association between women with previous uterine myoma and the risk of ovarian cancer.


This population-based case-control study was conducted using the Taiwan National Health Insurance Research Database between 2006 and 2010. We identified 4,088 adult women with newly diagnosed ovarian cancer with 16,348 women without ovarian cancer matched for age, urbanization level, income and initial diagnosis date. Logistic regression analyses were used to evaluate the variables associated with ovarian cancer. In addition, the effect of surgical interventions on the risk of ovarian cancer was also evaluated.


Women with previous uterine myoma were more likely than those who did not to have ovarian cancer (adjusted odds ratio [aOR]=2.26; 95% confidence interval [CI]=2.06-2.49). Patients with uterine myoma who either received (aOR=1.79; 95% CI=1.51-2.13) or did not receive hormone replacement therapy (aOR=2.51; 95% CI=2.24-2.82) experienced a significantly higher risk of ovarian cancer than those without uterine myoma, respectively. However, patients with uterine myoma who underwent either myomectomy (aOR=0.55; 95% CI=0.39-0.77) or hysterectomy (aOR=0.33; 95% CI=0.26-0.42) had a significantly lower risk of ovarian cancer.


The results revealed that a significantly higher risk of ovarian cancer in women with previous uterine myoma, through an indirect mechanism. Furthermore, a lower risk of ovarian cancer was observed in women who underwent surgical removal of the uterine myoma.


Hormone Replacement Therapy; Hysterectomy; Leiomyoma; Myomectomy; Ovarian Neoplasm

Supplemental Content

Full text links

Icon for Asian Society of Gynecologic Oncology; Korean Society of Gynecologic Oncology Icon for PubMed Central
Loading ...
Support Center