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Biosci Trends. 2019;13(3):284-285. doi: 10.5582/bst.2019.01155.

New thoughts in exploring the pathogenesis, diagnosis, and treatment of threatened abortion.

Zhou J1,2,3, Huang Z1,2,3, Pan X1,2,3, Leung WT1,2,3, Li C1,2,3, Chen L1,2,3, Zhang Y1,2,3, Wang L1,2,3, Sima Y1,2,3, Zhang N1,2,3, Qiu X1,2,3, Li L1,2,3, Wang L1,2,3.

Author information

1
Laboratory for Reproductive Immunology, Hospital & Institute of Obstetrics and Gynecology, Shanghai Medical College, Fudan University.
2
The Academy of Integrative Medicine, Fudan University.
3
Shanghai Key Laboratory of Female Reproductive Endocrine-related Diseases.

Abstract

Threatened abortion is a common complication of pregnancy. Since the underlying mechanisms behind this condition are complicated, predicting and treating threatened abortion is a challenge for clinicians. Interestingly, a recent article in Bioscience Trends (Biosci Trends 2019; DOI: 10.5582/bst.2019.01111) revealed a higher, not lower, level of ꞵ-human chorionic gonadotropin (hCG) and estrogen during the first 6 weeks of pregnancy, suggesting a novel association between ꞵ-hCG, estrogen, and threatened abortion. Unfortunately, this study was limited by its small sample size, unconvincing trial design, and inadequate exploration of the underlying mechanisms. This low-quality evidence indicates that a higher level of ꞵ- hCG and estrogen is associated with threatened abortion. However, that work provided some new insights for further studies of threatened abortion.

KEYWORDS:

estrogen; threatened abortion; ꞵ-human chorionic gonadotropin

PMID:
31327799
DOI:
10.5582/bst.2019.01155
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