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Drug Discov Ther. 2019;13(3):133-136. doi: 10.5582/ddt.2019.01025.

Additive effects of Kothala himbutu (Salacia reticulata) extract and a lactic acid bacterium (Enterococcus faecalis YM0831) for suppression of sucrose-induced hyperglycemia in an in vivo silkworm evaluation system.

Author information

1
Genome Pharmaceuticals Institute Co., Ltd.
2
Molecular Cell Biology Laboratory, Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, Musashino University.
3
Teikyo University Institute of Medical Mycology.
4
Department of Microbiology, Meiji Pharmaceutical University.

Abstract

Using a silkworm evaluation system, we previously evaluated various substances that suppress postprandial hyperglycemia. Enterococcus faecalis YM0831, a lactic acid bacterium that inhibits glucose uptake by the human intestinal Caco-2 cell line, exhibited hyperglycemia-suppressing effects in the silkworm system. In the present study, we found that Kothala himbutu (Salacia reticulata) extract, a traditional medicine containing α-glucosidase inhibitors, suppressed sucrose-induced hyperglycemia in the silkworm system. Moreover, combined oral administration of lactic acid bacteria YM0831 with Kothala himbutu extract had stronger suppressive effects on sucrose-induced hyperglycemia than single administration of either component. These findings suggest that the silkworm system provides a simple way to evaluate the effects of supplements on the suppression of blood glucose level induced by sucrose ingestion.

KEYWORDS:

Kothala himbutu; Salacia reticulata; hyperglycemia; lactic acid bacteria; silkworm

PMID:
31327788
DOI:
10.5582/ddt.2019.01025
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