Send to

Choose Destination
J Neurogastroenterol Motil. 2019 Jul 1;25(3):394-402. doi: 10.5056/jnm19059.

Multicenter Prospective Study of Laparoscopic Nissen Fundoplication for Gastroesophageal Reflux Disease in Korea.

Author information

Department of Surgery, Korea University College of Medicine, Seoul, Korea.
Department of Surgery, Chung-Ang University College of Medicine, Seoul, Korea.
Department of Surgery, The Catholic University of Korea College of Medicine, Incheon, Korea.
Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea.
Department of Surgery, Ajou University College of Medicine, Suwon, Korea.
Department of Surgery, Kosin University College of Medicine, Busan, Korea.
Department of Pharmacy, Kyungpook National University, Daegu, Korea.



This multicenter study aims to evaluate the effect and feasibility of anti-reflux surgery compared with medical treatment for gastroesophageal reflux disease (GERD).


Patients with GERD who were undergoing medical treatment with proton pump inhibitors for more than 8 weeks and those who were scheduled to undergo anti-reflux surgery were enrolled. Efficacy of pre-operative medical treatment was evaluated retrospectively and effect of anti-reflux surgery was prospectively evaluated at 1 week and 3 months after surgery. Quality of life (QOL) was also investigated before and after surgery.


Between February and October 2018, 51 patients underwent laparoscopic Nissen fundoplication for treating GERD at 5 hospitals in Korea. Thirty-four patients (66.7%) showed poor proton pump inhibitor response. At 3 months after surgery, heartburn was completely resolved in 87.9% patients and partially improved in 9.1%. Acid regurgitation was completely resolved in 82.9% and partially improved in 11.4%. Atypical extraesophageal symptoms were completely controlled in 45.5% and partially controlled in 36.4%. GERD-related QOL scores at 1 week after surgery significantly improved compared with pre-operative scores. There was no difference in GERD-related QOL scores between 1 week and 3 months after surgery. General QOL measured with European QOL-5 dimensions and health-related QOL instrument with 8 items significantly improved after anti-reflux surgery. Satisfaction with treatment was significantly higher after surgery than before surgery (72.5% vs 11.8%, P < 0.001).


Anti-reflux surgery improved GERD symptoms and QOL in patients. Anti-reflux surgery is an effective treatment option compared with medical treatment for GERD patients selected for surgical treatment.


Fundoplication; Gastroesophageal reflux; Laparoscopy; Quality of life

Supplemental Content

Full text links

Icon for Inforang Icon for PubMed Central
Loading ...
Support Center