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Arch Gerontol Geriatr. 2019 Sep - Oct;84:103903. doi: 10.1016/j.archger.2019.103903. Epub 2019 Jul 3.

Association of oxytocin levels and oxytocin receptor gene polymorphism (rs2254298) with cardiovascular risk factors in Brazilian elderly from Primary Health Care.

Author information

1
Biomedical Gerontology Program of the School of Medicine, Pontifical Catholic University of Rio Grande do Sul (IGG-PUCRS), Porto Alegre/RS, Brazil.
2
Labvitrus, Porto Alegre, RS, Brazil.
3
Biomedical Gerontology Program of the School of Medicine, Pontifical Catholic University of Rio Grande do Sul (IGG-PUCRS), Porto Alegre/RS, Brazil. Electronic address: maria.gottlieb@pucrs.br.

Abstract

BACKGROUND:

Morbidity and mortality from cardiovascular disease is a typical phenomenon in the elderly, and are related to unfavorable genetic, hormonal and environmental (lifestyle) interactions. In this context, oxytocin (OT) seems plays a key role in the development of CVD by performing important actions in metabolism energy and hemodynamic variables.

OBJECTIVE:

To verify if there is an association between (OT) levels and the oxytocin receptor gene (OXTR) polymorphism (rs2254298) with cardiovascular risk factors (CRF) in the elderly.

METHODS:

This was a cross-sectional study in community-dwelling elderly attending primary health care. The genotyping was done using the polymerase chain reaction technique. The CRF factors investigated included hypertension, diabetes mellitus, dyslipidemia, sedentary lifestyle, and obesity. Levels of triglycerides (TGC) postprandial and glucose were measured in capillary blood. OT and cortisol levels were measured by enzyme-linked immunosorbent assay (ELISA).

RESULTS:

The sample comprised 177 elderly individuals. OT levels showed a significant negative correlation with postprandial triglycerides (p = 0.030) and BMI (p = 0.019). OT levels were also associated with leanness (p = 0.005). On Poisson regression analysis, OT remained a predictor for leanness (p = 0.010). No significant associations were observed between the OXTR polymorphism and CRF.

CONCLUSION:

The results suggest that Postprandial TGC levels are increased, while OT levels are decreased, and this hormone was significantly elevated in lean elderly. Future studies are needed to confirm these findings, and the role of OT in metabolic parameters.

KEYWORDS:

Aging; Cardiovascular Risk factors; Genetic polymorphism; OXTR polymorphism; Oxytocin

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