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Sci Rep. 2019 Jul 19;9(1):10532. doi: 10.1038/s41598-019-46931-0.

Genetic Polymorphisms in ADORA2A and CYP1A2 Influence Caffeine's Effect on Postprandial Glycaemia.

Author information

1
Applied Neuromuscular Physiology Laboratory, Oklahoma State University, Stillwater, OK, USA.
2
Laboratory for Applied Nutrition and Exercise Science, Oklahoma State University, Stillwater, OK, USA.
3
Nutritional Sciences, Oklahoma State University, Stillwater, OK, USA.
4
Applied Neuromuscular Physiology Laboratory, Oklahoma State University, Stillwater, OK, USA. nathaniel.jenkins@okstate.edu.
5
Laboratory for Applied Nutrition and Exercise Science, Oklahoma State University, Stillwater, OK, USA. nathaniel.jenkins@okstate.edu.

Abstract

The liver enzyme cytochrome P450 1A2 (CYP1A2) is responsible for 90% of caffeine metabolism, while caffeine exerts many of its effects via antagonist binding to adenosine A2a receptors (ADORA2A). This study aimed to examine whether functional single nucleotide polymorphisms (SNPs) in 1976T > C (ADORA2A; rs5751876) and -163C > A (CYP1A2; rs762551) influence the effect of caffeine on the postprandial glucose (GLU) response to a carbohydrate meal. We report that individuals with the 1976T > C CC, but not CT/TT genotypes display elevated GLU levels after consuming caffeine and carbohydrate (CHO + CAFF) versus carbohydrate only (CHO). The GLU area under the curve (AUC) was also greater during the CHO + CAFF condition compared to the CHO condition in CC, but not the CT/TT genotypes. The -163C > A AC/CC, but not AA, genotypes displayed greater GLU concentrations 60-min post meal during CHO + CAFF versus CHO. Our data suggest that caffeine-induced impairments in postprandial glycaemia are related to 1976T > C and -163C > A SNPs.

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