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Transfus Apher Sci. 2019 Jul 10. pii: S1473-0502(19)30136-3. doi: 10.1016/j.transci.2019.06.029. [Epub ahead of print]

Fatal hemolytic disease of the fetus and newborn caused by anti-Jra antibody: A case report and literature review.

Author information

1
Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea.
2
Seegene Medical Foundation, Seoul, Republic of Korea.
3
Department of Laboratory Medicine, Kangdong Sacred Heart Hospital, Seoul, Republic of Korea.
4
Department of Laboratory Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
5
Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea. Electronic address: daehyuni1118@amc.seoul.kr.
6
Department of Obstetrics and Gynecology, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea.

Abstract

The Jra antigen of the JR blood group system is a highly prevalent red blood cell antigen. Although anti-Jra-associated hemolytic disease of the fetus and newborn (HDFN) is generally considered mild-to-moderate, a rare fatal case was recently reported. We report the third example of HDFN-related anti-Jra with fatal outcomes. The clinical significance of anti-Jra antibody as a cause of HDFN should be reassessed.

KEYWORDS:

ABCG2; Anti-Jr(a); Fatality; Hemolytic disease of the fetus and newborn

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