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Am J Cardiol. 2019 Jun 26. pii: S0002-9149(19)30718-0. doi: 10.1016/j.amjcard.2019.06.015. [Epub ahead of print]

Trends of Inpatient Venous Thromboembolism in United States Before and After the Surgeon General's Call to Action.

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Division of Hematology-Oncology, University of Kansas Medical Center, Kansas City, Kansas. Electronic address:
Division of Hematology-Oncology, Baystate Medical Center, Springfield, Massachusetts.
Division of Neurology, University of Connecticut, Hartford, Connecticut.
Division of Hematology-Oncology, Yale New Haven Hospital, New Haven, Connecticut.
University of Pittsburgh, Pittsburgh, Pennsylvania.
Division of Hematology-Oncology, Univerisity of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Division of Hematology-Oncology, University of Kansas Medical Center, Kansas City, Kansas.


Venous thromboembolism (VTE) is an important cause of morbidity and mortality in the United States (US). The increasing rates of VTE in the US resulted in the surgeon general issuing a call to action to reduce VTE in 2008. The objective of our study was to analyze the national trends of inpatient VTE in the US from 2004 to 2013 (5 years before and after 2008). We used the dataset National Inpatient Sample, Healthcare Cost and Utilization Project and measured trends of inpatient VTE by annual % change using joinpoint regression software. From 2004 to 2013 the National Inpatient Sample contained data on 78 million hospitalizations (weighted n = 385 million). In these 1.6 million had a diagnosis of VTE (2.0%, weighted n = 7.7 million) including 1.2 million with deep venous thrombosis (DVT) (1.53%, weighted n = 5.9 million) and 588,878 with pulmonary embolism (PE) (0.74%, weighted n = 2.8 million). Joinpoint regression analysis showed that rates of DVT and PE are increasing consistently from 2004 to 2013(1.27% to 1.80% for DVT and 0.52% to 0.92% for PE). The increasing rates of DVT and PE were consistent in all subgroups except few exceptions. In conclusion inpatient VTE rates continue to rise even after 5 years from the surgeon general's a call to action except in certain high-risk patients. Further research is needed to curb the VTE in patients especially among those perceived to be at lower risk of VTE.

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