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J Agric Food Chem. 2019 Aug 7;67(31):8425-8430. doi: 10.1021/acs.jafc.9b03085. Epub 2019 Jul 29.

Opportunities and Challenges Using Non-targeted Methods for Food Fraud Detection.

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Institute of Food and Nutraceutical Science, School of Agriculture and Biology , Shanghai Jiao Tong University , Shanghai 200240 , People's Republic of China.
Fonterra Research and Development Centre , Dairy Farm Road , Palmerston North 4442 , New Zealand.
United States Pharmacopeial Convention , 12601 Twinbrook Parkway , Rockville , Maryland 20852 , United States.


In recent years, non-targeted methods have been a popular "buzz" phrase in food fraud detection. Using analytical instrumentation techniques, non-targeted methods have been developed and applied in many food and agricultural situations. However, confusion and misstatements remain regarding how the methods are used. This perspective will discuss the definitions related to non-targeted testing, the procedure of developing and validating methods, the techniques and data analysis, and opportunities and challenges regarding the use of this class of analytical methods. The perspective seeks to provide readers with the latest information regarding recent advances in the use of non-targeted methods.


chemometrics; food fraud; non-targeted methods; untargeted methods

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