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J Cosmet Dermatol. 2019 Jul 19. doi: 10.1111/jocd.13074. [Epub ahead of print]

Cosmetic use of three topical moisturizers following glycolic acid facial peels.

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GlaxoSmithKline Consumer Healthcare Brazil - Medical Affairs and Clinical Operations, São Paulo, Brazil.
GlaxoSmithKline Consumer Healthcare, Research and Development - Skin Health, Weybridge, UK.



Facial chemical exfoliation (peeling) involves using a chemical agent to insult the skin and damage the cutaneous barrier, to reduce the signs of aging. The use of a moisturizer is advised postprocedure to promote repair of the epidermis. Biomimic moisturizer formulations may be effective treatment options for repair following facial peeling.


The aim of this study was to assess the local tolerance and cosmetic efficacy of three topical moisturizers (Physiogel® moisturizing creams), used after a 70% glycolic acid facial peel.


Three randomized, evaluator-blind, parallel group studies were performed. Subjects were healthy females aged 30-60 years with moderate to advanced photoaged skin (Glogau photoaging type II-III). All included a screening visit, a 7-day washout period, a 70% glycolic acid facial peeling procedure, and randomization to a 14-day treatment period with one of the three test products vs control.


The primary endpoint was reached in all three studies; all completed subjects in the test groups received a favorable dermatologist global assessment score for tolerance at Day 14 (postchemical peel). Secondary assessments of local tolerance based on dermatologist and subject self-assessment scores demonstrated improvements from baseline. No treatment-related adverse events were reported in any study. Benefits for the test products were also observed in secondary efficacy analyses of transepidermal water loss and moisturization.


These studies have demonstrated the local tolerance and cosmetic efficacy of three moisturizing skin care products, when used for skin recovery after superficial chemical peeling on the face.


Physiogel®; biomimic; chemical peel; facial peel; skin barrier


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