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Proteomics. 2019 Nov;19(21-22):e1800485. doi: 10.1002/pmic.201800485. Epub 2019 Sep 5.

High-Quality Biobanks: Pivotal Assets for Reproducibility of OMICS-Data in Biomedical Translational Research.

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Biothèque Wallonie Bruxelles (BWB),, Brussels, 1070, Belgium.
Department of Public Health and Primary Care, Faculty of Medicines and Health Sciences,, Ghent University, Ghent, 9052, Belgium.


Human biospecimen samples (HBS) and associated data stored in biobanks (also called "biotrusts," "biorepositories," or "biodistributors") are very critical resources for translational research. As HBS quality is decisive to the reproducibility of research results, biobanks are also key assets for new developments in precision medicine. Biobanks are more than infrastructures providing HBS and associated data. Biobanks have pioneered in identifying and standardizing sources of preanalytical variations in HBS, thus paving the way for the current biospecimen science. To achieve this milestone, biobankers have successively assumed the role of "detective," and then "architect," to identify new detrimental impact of preanalytical variables on the tissue integrity. While standardized methods in omics are required to be practiced throughout research communities, the accepted best practices and standards on biospecimen handling are generally not known nor applied by researchers. Therefore, it is mandatory to raise the awareness within omics communities regarding not only the basic concepts of collecting, storing, and utilizing HBS today, but also to suggest insights on biobanking in the cancer omics context.


biobank; biodistributor; biorepository; biotrust; human biospecimen sample


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