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Pediatrics. 2019 Aug;144(2). pii: e20190514. doi: 10.1542/peds.2019-0514. Epub 2019 Jul 18.

Cognitive and Behavioral Impact on Children Exposed to Opioids During Pregnancy.

Author information

1
Substance Abuse and Mental Health Services Administration, Rockville, Maryland; justine.larson@samhsa.hhs.gov.
2
College of Medicine, Florida State University, Tallahassee, Florida.
3
Case Western Reserve University, Cleveland, Ohio.
4
Children's Specialized Hospital, Mountainside, New Jersey.
5
School of Medicine, Tufts University, Boston, Massachusetts.
6
Virginia Commonwealth University, Richmond, Virginia.
7
School of Public Health, University of Colorado Denver, Denver, Colorado; and.
8
College of Medicine, University of Kentucky, Lexington, Kentucky.

Abstract

The developmental impact of opioid use during pregnancy is a subject of ongoing debate. Short-term neonatal outcomes, such as lower birth weight and neonatal abstinence syndrome, are the most well-recognized outcomes. However, knowledge gaps exist regarding longer-term neurocognitive and mental health outcomes. In this article, we summarize an expert panel discussion that was held in April 2018 by the Substance Abuse and Mental Health Services Administration and attended by national experts in the field of perinatal opioid exposure and its impact on child development. Despite the challenges with research in this area, there is emerging literature revealing an association between neonates exposed to opioids in utero and longer-term adverse neurocognitive, behavioral, and developmental outcomes. Although adverse sequalae may not be apparent in the neonatal period, they may become more salient as children develop and reach preschool and school age. Multiple variables (genetic, environmental, and biological) result in a highly complex picture. The next steps and strategies to support families impacted by opioid use disorder are explored. Model programs are also considered, including integrated care for the child and mother, parenting supports, and augmentations to home visiting.

PMID:
31320466
DOI:
10.1542/peds.2019-0514

Conflict of interest statement

POTENTIAL CONFLICT OF INTEREST: The authors have indicated they have no potential conflicts of interest to disclose.

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