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BMC Biol. 2019 Jul 18;17(1):59. doi: 10.1186/s12915-019-0678-9.

Viral hijacking of cellular metabolism.

Author information

1
Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA, 90095, USA.
2
Department of Pediatrics, Division of Hematology/Oncology, David Geffen School of Medicine, UCLA, Los Angeles, CA, 90095, USA.
3
Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA, 90095, USA. hchristofk@mednet.ucla.edu.
4
Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA, 90095, USA. hchristofk@mednet.ucla.edu.
5
Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, UCLA, Los Angeles, CA, 90095, USA. hchristofk@mednet.ucla.edu.

Abstract

This review discusses the current state of the viral metabolism field and gaps in knowledge that will be important for future studies to investigate. We discuss metabolic rewiring caused by viruses, the influence of oncogenic viruses on host cell metabolism, and the use of viruses as guides to identify critical metabolic nodes for cancer anabolism. We also discuss the need for more mechanistic studies identifying viral proteins responsible for metabolic hijacking and for in vivo studies of viral-induced metabolic rewiring. Improved technologies for detailed metabolic measurements and genetic manipulation will lead to important discoveries over the next decade.

PMID:
31319842
PMCID:
PMC6637495
DOI:
10.1186/s12915-019-0678-9
[Indexed for MEDLINE]
Free PMC Article

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