Send to

Choose Destination
Clin Neurophysiol. 2019 Sep;130(9):1611-1619. doi: 10.1016/j.clinph.2019.05.034. Epub 2019 Jul 1.

A network approach to investigate the bi-hemispheric synchrony in absence epilepsy.

Author information

Department of Mathematics & Computer Science, Eindhoven University of Technology, Eindhoven, The Netherlands; Academic Center for Epileptology Kempenhaeghe & Maastricht University Medical Center, Heeze, The Netherlands. Electronic address:
Academic Center for Epileptology Kempenhaeghe & Maastricht University Medical Center, Heeze, The Netherlands.
Department of Neurology, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands.
Biological Psychology, Donders Centre of Cognition, Radboud University, Nijmegen, The Netherlands.



Our objective was to unravel the dynamics underlying spike-and-wave discharges (SWDs) characteristic for childhood absence epilepsy.


SWDs were recorded for a cohort of 28 children using magnetoencephalography. Non-linear association analyses and a graph theoretical metric of local connectedness (LoC) were utilized in a sliding window starting one s before till four s after ictal onset.


A focal pattern of bilateral frontal and parietal areas with high LoC during the spikes alternated by generalized patterns during the waves was found for all children studied during generalization of the SWDs. In the interval preceding the generalization a focal parietal region was most often (16/28) encountered and less often an occipital (4/28), temporal (5/28) or frontal (3/28) region. 55% of the children with a parietal/occipital focal onset became seizure free after the administration of two anti-epileptic drugs, and only 12.5% with a temporal/frontal focal onset.


The transition from the interictal to the ictal state is for some of the children characterized by dominant LoC at either the parietal/occipital and for others at the frontal/temporal region.


The focal onset of the SWDs varies in location among the children with a clinical similar profile, who, however, seemingly are differing with regard to seizure control.


Childhood absence epilepsy; Driving sources; Local connectivity mapping; Treatment response

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center